The RBBP8 antibody from Wuhan Fine Biotech Co., Ltd. is a Rabbit Polyclonal antibody to Rbbp8. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The RBBP8 antibody has been validated for the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Endonuclease that cooperates with the MRE11-RAD50-NBN(MRN) complex in processing meiotic and mitotic double-strand breaks(DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining(A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations